fluff is a software package that allows for simple exploration, clustering and visualization of high-throughput sequencing experiments mapped to a reference genome. The package contains three command-line tools to generate publication-quality figures:

  • heatmap: clustering and visualization in a heatmap
  • bandplot: visualization of average profiles of clustered data in small multiples
  • profile: creating genome browser-like genomic profiles

Quick Installation

The most straightforward way to install fluff is with conda using the bioconda channel (Python 2.7 only):

$ conda install biofluff -c bioconda

Quick Usage

See the quick examples in the Usage section.


If you find fluff useful, please cite:

Georgiou G, van Heeringen SJ. (2016) fluff: exploratory analysis and visualization of high-throughput sequencing data. PeerJ 4:e2209 doi: 10.7717/peerj.2209.